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SUMMARY:In vivo studies of cellular and subcellular mechanisms that build 
 the vertebrate brain - Professor Jon Clarke\, King's College London
DTSTART:20170216T160000Z
DTEND:20170216T170000Z
UID:TALK70436@talks.cam.ac.uk
CONTACT:Maria Schacker
DESCRIPTION:We are examining the role of cell intrinsic behaviours\, cues 
 from the extracellular matrix and biomechanics during the early developmen
 t of the vertebrate brain. We use the zebrafish embryo as our model becaus
 e its accessibility and superior optical qualities allow high resolution i
 n vivo imaging. Our work examines the role of cell division in morphogenes
 is\, the factors that orchestrate development of the ventricular surface a
 nd the factors that orient the inside-out axis of the developing brain. Ad
 ditionally we reveal a novel self-renewing progenitor in the brainstem tha
 t not only generates a distinct neural lineage but also acts as a dynamic 
 architectural link between two very distinct types of epithelium.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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