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SUMMARY:Live imaging inflammation in wound healing and cancer - Professor 
 Paul Martin\, University of Bristol
DTSTART:20170223T160000Z
DTEND:20170223T170000Z
UID:TALK70437@talks.cam.ac.uk
CONTACT:Maria Schacker
DESCRIPTION:We model various aspects of tissue repair in several genetical
 ly tractable model organisms from the fruitfly\, Drosophila\, through to m
 ice. We know that inflammation causes scarring and is aberrant in chronic 
 wounds and so we use Drosophila and the translucent zebrafish\, which are 
 both amenable to live imaging and mathematical modelling\, to make movies 
 of immune cell migration into the wound and to dissect the genetics of inf
 lammatory cell recruitment towards tissue damage. Recently\, we have also 
 begun investigating aspects of cancer inflammation\, in particular paralle
 ls between the wound damage attractants and the signals that draw immune c
 ells to early clones of transformed cells before they progress to cancers.
  We find that clones of transformed cells deprived of immune cells prolife
 rate at a slower rate suggesting that growth signals\, which include prost
 aglandins\, are delivered to the transformed cells by immune cells. Since 
 surgery is one of the most effective means of treating cancer we have begu
 n to use zebrafish to model cancer surgery\, in particular investigating h
 ow the wound inflammatory response impacts on immune cell recruitment to n
 earby transformed cells and what might be the downstream consequences of t
 his.  Most recently we have also begun to investigate how adipocytes and o
 besity might link into wound repair and cancer.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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