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SUMMARY:Tracking nonequilibrium in living cells - Étienne Fodor (Universi
 ty of Cambridge)
DTSTART:20170201T130500Z
DTEND:20170201T140000Z
UID:TALK70831@talks.cam.ac.uk
CONTACT:Julius Bier Kirkegaard
DESCRIPTION:Living systems operate far from equilibrium due to the continu
 ous injection of energy provided by ATP supply. The dynamics of the intrac
 ellular components\, such as proteins\, organelles and cytoskeletal filame
 nts\, are driven by both thermal equilibrium fluctuations\, and active sto
 chastic forces generated by the molecular motors. Tracer particles are inj
 ected in living cells to study these fluctuations. To sort out genuine non
 equilibrium fluctuations from purely thermal effects\, measurements of spo
 ntaneous tracer fluctuations and of response are combined. We theoreticall
 y rationalize the observed fluctuations with a phenomenological model. Thi
 s model\, in turn\, allows us to quantify the time and energy scales of ac
 tive fluctuations in two different experimental systems -- living melanoma
  cells and living mouse oocytes -- and to estimate the energy transfers op
 erating in such systems.
LOCATION:MR11\, Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
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