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SUMMARY:&quot\;Regulation of X-chromosome inactivation in human developmen
 t&quot\; - Dr Claire Rougeulle\; The National Centre for Scientific Resear
 ch (CNRS)\, France
DTSTART:20170228T130000Z
DTEND:20170228T140000Z
UID:TALK70871@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Sex-chromosome dosage compensation is essential in most metazo
 an\, yet the developmental timing and the underlying strategies are remark
 ably variable\, even amongst placental mammals. In the latter\, dosage com
 pensation is achieved through the inactivation of one X chromosome in fema
 les\, a process that has been so far mostly studied in the mouse\, where a
 ctors and mechanisms have been characterized. Here we will discuss new ins
 ights into how the activity of the X chromosome is regulated in human earl
 y development\, and how long noncoding RNAs are contributing to this proce
 ss.
LOCATION:Babraham - The Brian Heap Seminar Room
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