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SUMMARY:&quot\;RhoGEFs as signaling platforms of chemotactic GPCRs&quot\; 
  - José Vázquez-Prado\; Department of Pharmacology\, The Center for Rese
 arch and Advanced Studies of the National Polytechnic Institute (CINVESTAV
 -IPN)  Mexico
DTSTART:20170309T130000Z
DTEND:20170309T140000Z
UID:TALK70872@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Cancer cells and stroma cells in tumors secrete chemotactic ag
 onists that exacerbate invasive behavior\, promote tumor-induced angiogene
 sis\, and recruit protumoral bone marrow-derived cells. In response to sha
 llow gradients of chemotactic stimuli recognized by G protein-coupled rece
 ptors (GPCRs)\, Gbg-dependent effectors such as Phosphoinositide-3-kinases
  and Rac guanine nucleotide exchange factors\, such as P-Rex1\, contribute
  to the activation of Rho GTPases and their cytoskeletal-remodeling effect
 ors. P-Rex1\, as many other Rho guanine nucleotide exchange factors coexpr
 essed in protumoral cells\, is a multidomain protein that interacts with m
 ultiple regulators and upstream signaling partners. The role of P-Rex1 as 
 a signaling platform of chemotactic GPCRs will be discussed based on its i
 nteractions with GPCRs\, Gbg and the serine/threonine kinases mTOR and PKA
 . Overall\, the proven relevance of multiple chemokines in oncogenic setti
 ngs has pointed to RhoGEFs as potential pharmacologic targets in cancer re
 search.\n\n
LOCATION:Babraham - The Brian Heap Seminar Room
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