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SUMMARY:&quot\;Defining the relationship between stem and progenitor cells
  in the intestinal epithelium&quot\;  - Dr Doug Winton\; Cambridge Institu
 te\, CRUK
DTSTART:20170309T160000Z
DTEND:20170309T170000Z
UID:TALK70873@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:The intestinal epithelium is maintained by a population of ste
 m cells that are restricted to the base of glandular crypts. At the crypt 
 base there is considerable heterogeneity in the behaviour of cells and in 
 expression of phenotypic markers that associate with stem cell self-renewa
 l. The relative self-renewing activity of any given subset of cells may va
 ry in health and disease. For these reasons we attempt to treat the cells 
 of the lower crypt as a community and to understand self-renewal in terms 
 of overarching behaviours. This is achieved largely in mouse models by est
 ablishing the rules governing clonal dynamics by which long-lived clones a
 rise and undergo expansions to populate entire crypts. With these rules es
 tablished there a number of applications that allow both fundamental biolo
 gical questions to be addressed such as defining the distinction between s
 tem cells and their more committed daughters. Further to develop approache
 s to similar analyses in patients with a view to understanding stem cell d
 efects in disease.
LOCATION:Babraham - The Brian Heap Seminar Room
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