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SUMMARY:EU Life Lecture - &quot\;Genomic approaches to study chromosome ar
 chitecture and function&quot\; - Prof. Bas van Steensel\; The Netherlands 
 Cancer Institute  (NKI) 
DTSTART:20170313T130000Z
DTEND:20170313T140000Z
UID:TALK70874@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Chromatin is probably the most complex molecular ensemble in t
 he cell. It consists of genomic DNA bound by hundreds of protein and RNA m
 olecules. All of these components work in concert\, and cannot be fully un
 derstood unless they are studied in their complete context. In addition\, 
 the spatial organization of interphase chromosomes is thought to be of key
  importance for genome expression and maintenance. Yet\, this three-dimens
 ional chromosome organization and its impact on gene regulation and other 
 functions are still poorly understood. In order to gain insight into these
  fundamental processes\, we take a broad integrative genomics approach\, u
 sing both fruit fly and mammalian cells as model systems. We conduct our s
 tudies in the living cell\, in the context of the entire genome. We develo
 p and apply new genomics techniques to reveal the interplay among many chr
 omatin proteins\, to visualize the architecture of chromosomes inside the 
 nucleus\, and to detect the genome-wide effects of these factors on gene e
 xpression. We analyze the large datasets that we generate using a range of
  bioinformatics approaches.
LOCATION:Babraham - The Brian Heap Seminar Room
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