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SUMMARY:&quot\;Group 2 Innate Lymphoid cells at the interface between inna
 te and adaptive immunity&quot\;  - Dr Tim Halim\; MRC Laboratory of Molecu
 lar Biology\, Cambridge
DTSTART:20170321T130000Z
DTEND:20170321T140000Z
UID:TALK70875@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Group 2 innate lymphoid cells (ILC2) are a newly discovered su
 bset of lymphocytes that are known to be prolific producers of inflammator
 y cytokines. We have found that ILC2 are tissue resident cells in the airw
 ays\, and can be rapidly activated by epithelial-derived stress factors su
 ch as interleukin (IL)-33 to promote acute allergic (Type-2) lung inflamma
 tion. Moreover\, we have also shown that ILC2\, through production of IL-1
 3\, can influence the migration of lung dendritic cells (DC) to the draini
 ng lymph nodes. It is there that DCs encounter and subsequently activate n
 aïve CD4 T cells\, which become polarized to a T helper 2 (TH2) cell phen
 otype. Subsequently\, lung ILC2s also stimulate lung DCs to produce CCL17\
 , which attracts the memory TH2 cells into the lungs. Thus\, ILC2 are an i
 mportant regulator of tissue-specific innate and adaptive type-2 inflammat
 ion\, and provide a critical link between the epithelium and innate and ad
 aptive immune system. 
LOCATION:Babraham - The Brian Heap Seminar Room
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