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SUMMARY:“Creating New In-Roads for Cancer-Specific T Cells” - Prof. Aw
 en Gallimore\; Cardiff University\, School of Medicine\, Wales\, UK
DTSTART:20170330T130000Z
DTEND:20170330T140000Z
UID:TALK70876@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:One limitation to successful cancer immunotherapy is the immun
 osuppressive effects of Tregs which are highly enriched in many tumours. T
 his talk will focus on the impact of these cells in the context of human c
 olorectal cancer (CRC) and in mouse models of cancer.\nIn the case of CRC\
 , Tregs are associated with disease progression and a paucity of T cell re
 sponses to tumour-associated antigens. Modulation of Treg numbers restores
  these immune responses\, possibly leading to control of disease progressi
 on.\nIn the case of mouse models\, the talk will focus on the impact of Tr
 eg on the tumour vasculature.  Modulating Treg numbers/activity results in
  alterations to the vasculature that serve to increase the frequency of tu
 mour-infiltrating T cells and improve control of tumour growth. These find
 ings could inform future therapeutic approaches to increase access of effe
 ctor cells to the tumour microenvironment.\n
LOCATION:Babraham - The Brian Heap Seminar Room
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