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SUMMARY:EU Life Lecture - “The interplay between neuronal activity and a
 ctin dynamics in synaptic tagging and capture” - Dr Rosalina Fonseca\; C
 ellular and Systems Neurobiology\, Gulbenkian Institute of Science (IGC)
DTSTART:20170331T120000Z
DTEND:20170331T130000Z
UID:TALK70877@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Long-lasting forms of plasticity\, such as long-term potentiat
 ion (LTP) or long-term depression (LTD) require the allocation of plastici
 ty-related proteins (PRPs) in an input-specific manner - synaptic tagging 
 and capture. I will present recent evidence from our laboratory supporting
  the hypothesis that the synaptic tag is a transient state of the synapses
  that allows plasticity to occur. I will also show that the modulation of 
 synaptic actin cytoskeleton is necessary for the induction of LTP and LTD 
 and it is involved in synaptic tagging and capture in LTD and LTP. Interes
 tingly\, pharmacological modulation of the actin cytoskeleton can create a
 n artificial synaptic tag that can capture PRPs. The dynamics of the actin
  cytoskeleton is activity-dependent and modulated by CaMKII activation. Th
 ese observations strengthen our hypothesis that modulation of actin is a g
 eneral mechanism that provides an input-specific signal for PRPs capture a
 nd is independent of the upstream events triggered by LTP or LTD induction
 . We are now imaging actin dynamics\, using STED microscopy\, to analyse o
 ur homo-synaptic and hetero-synaptic forms of plasticity modulate the syna
 ptic actin cytoskeleton.  
LOCATION:Babraham - The Brian Heap Seminar Room
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