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SUMMARY:&quot\;Regulatory feedback from nascent RNA to chromatin&quot\; - 
 Dr Richard Jenner\; UCL Cancer Institute\, University College London
DTSTART:20170315T130000Z
DTEND:20170315T140000Z
UID:TALK71037@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Transcription and chromatin function are regulated by proteins
  that bind DNA\, nucleosomes or RNA polymerase II\, with specific non-codi
 ng RNAs (ncRNAs) functioning to modulate their recruitment or activity. By
  contrast\, nascent pre-mRNA has primarily been considered a passive playe
 r in these processes. Focusing on polycomb repressive complex 2 (PRC2)\, I
  will present data from our lab that suggest that nascent pre-mRNA in fact
  plays an active role in regulating chromatin state. I will also discuss r
 ecent work revealing the transcriptional mechanisms underlying lineage spe
 cification of CD4+ T cells and how disregulation of these mechanisms is as
 sociated with increased risk of auto-inflammatory disease.
LOCATION:Babraham - The Brian Heap Seminar Room
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