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SUMMARY:Determining and approaching the physical limits of electron cryomi
 croscopy in biology - Dr. Christopher J. Russo ( MRC Laboratory for Molecu
 lar Biology\, U.K.)
DTSTART:20170302T120000Z
DTEND:20170302T130000Z
UID:TALK71344@talks.cam.ac.uk
CONTACT:William Grant
DESCRIPTION:In spite of recent advances in electron cryomicroscopy (cryo-E
 M)\, the structures of many proteins cannot be determined by cryo-EM becau
 se the individual protein molecules move during electron irradiation. This
  blurs the images so they cannot be aligned with each other to improve the
  signal to noise ratio and calculate a 3D density map. I will discuss the 
 types of movement at various length scales that occur in biological specim
 en during high energy electron irradiation\, and show how reducing this mo
 vement leads to improved micrographs and density maps. Further\, I will di
 scuss several physical limits important to cryo-EM and how they determine 
 the types of specimen which will ultimately be amenable to atomic resoluti
 on imaging with electrons.\n\n
LOCATION:TCM Seminar room\, 530 Mott building
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