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SUMMARY:The evolution and development of Drosophila segment patterning - E
 rik Clark (Department of Zoology)
DTSTART:20170315T173000Z
DTEND:20170315T193000Z
UID:TALK71380@talks.cam.ac.uk
CONTACT:Clara Sidor
DESCRIPTION:The Drosophila "segmentation cascade" is a paradigm for develo
 pmental\npattern formation and has been studied for decades. However\, two
  key\naspects of Drosophila segmentation are still not well understood. Fi
 rst\,\nthe more complex later stages of patterning\, involving the so-call
 ed\n"pair-rule" genes\, are not understood at the systems level. Second\, 
 the\nrelationship between the simultaneous\, "long-germ" mode of patternin
 g\nseen in Drosophila\, and the sequential\, "short-germ" mode of patterni
 ng\nseen in most other arthropods remains mysterious. I have been using a\
 ncombination of models and experiments to unravel the first problem\,\nrev
 ealing a previously unrecognised role for temporal information in\nspatial
 ly patterning the Drosophila embryo. Unexpectedly\, my findings\nalso shed
  light on the second problem\, as they suggest a simple\nevolutionary mech
 anism by which to transition between simultaneous and\nsequential modes of
  segmentation.
LOCATION:Gurdon Institute Tea Room
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