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SUMMARY:Shared developmental rules predict patterns of size evolution in v
 ertebrate segmented structures  - Kathryn Kavanagh (University of Massachu
 setts Dartmouth)
DTSTART:20170322T130000Z
DTEND:20170322T140000Z
UID:TALK71394@talks.cam.ac.uk
CONTACT:Olivia Tidswell
DESCRIPTION:Phenotypic diversity is not uniformly distributed\, but how bi
 ased patterns of evolutionary variation are generated and whether common d
 evelopmental mechanisms are responsible remains debatable. High-level “r
 ules” of self-organization and assembly are increasingly used to model o
 rganismal development\, even when the underlying cellular or molecular pla
 yers are unknown. One such rule\, the inhibitory cascade\, predicts that p
 roportions of segmental series derive from the relative strengths of activ
 ating and inhibitory interactions acting on both local and global scales (
 Kavanagh et al.\, 2007). Here we demonstrate that this developmental desig
 n rule explains population-level variation in segment proportions\, their 
 response to artificial selection and experimental blockade of putative sig
 nals\, and macroevolutionary diversity in limbs\, digits and somites. Toge
 ther with evidence from teeth\, these results indicate that segmentation a
 cross independent developmental modules shares a common regulatory “logi
 c”\, which has a predictable impact on both the short and long-term evol
 vability.  Such biased variational patterns can help paleontologists inter
 pret evolution of segments and modules in vertebrates.
LOCATION:Part II Lecture Theatre\, Department of Zoology
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