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SUMMARY:RNA-based regulation mechanism during transcription and translatio
 n - Professor Harald Schwalbe\,  Goethe Universität\, Frankfurt
DTSTART:20170315T103000Z
DTEND:20170315T113000Z
UID:TALK71615@talks.cam.ac.uk
CONTACT:23027
DESCRIPTION:Riboswitches are RNA-based regulation elements that modulate g
 ene expression at the level of transcription or translation. By binding of
  small molecular weight metabolites\, they can turn gene expression OFF or
  ON. In the talk\, biophysical studies and simulations will be presented t
 o delineate the molecular mechanism of riboswitches. For translational rib
 oswitches\, it is shown that three state mechanism are essential to mainta
 in riboswitch regulation over a broad temperature range (Reining et al.\, 
 2013). For transcriptional riboswitches\, the kinetic requirements to coup
 le mRNA synthesis\, RNA refolding and ligand binding are delineated (Helml
 ing et al.\, 2017).\n\n\nA. Reining\, S. Nozinovic\, K. Schlepckow\, F. Bu
 hr\, B. Fürtig\, *H. Schwalbe* (2013) Three-state mechanism couples ligan
 d and temperature sensing in riboswitches. Nature 499\, 355-359. \n\nC. He
 lmling\, A. Wacker\, M.T. Wolfinger\, I.L. Hofacker\, M. Hengesbach\, B. F
 ürtig\, *H. Schwalbe* (2017) NMR structural profiling of transcriptional 
 intermediates reveals riboswitch regulation by metastable RNA conformation
 s. J. Am. Chem. Soc.139\, 2647-2656.
LOCATION:Todd-Hamied Room\, Department of Chemistry\, Lensfield Road\, Cam
 bridge
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