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SUMMARY:“Targetting Tribbles 2 pseudokinase with drugs” - Dr Patrick E
 yers\; Department of Biochemistry\, Institute of Integrative Biology\, Uni
 versity of Liverpool
DTSTART:20170515T110000Z
DTEND:20170515T120000Z
UID:TALK71708@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION: \n \n\n\nPat is Reader in Chemical Biology in the Department 
 of Biochemistry\, Institute of Integrative Biology at the University of Li
 verpool\, where he runs a multidisciplinary cell signalling lab. His inter
 ests include all aspects of protein phosphorylation and the analysis of ki
 nase regulation\, human pseudokinases and pseudophosphatases\, and kinome-
 wide mechanisms of acquired drug resistance in cancer cells. He teaches me
 dical\, level 2 and 3 cell signalling courses at the University. \n Career
  research highlights:\n 1) Co-discovery of the protein kinase 'gatekeeper'
  residue in Ser/Thr kinases (1998)\n 2) First description of paradoxical a
 ctivation of RAF kinases by RAF inhibitors (1999)\n 3) Discovery of TPX2 a
 s a physiological activator of Aurora A (2003)\n 4) Rate-limiting roles fo
 r PKA and TPX2 in Xenopus cell cycles (2005\, 2008)\n 5) First crystal str
 uctures of Mps1\, a key phospho-regulator of the spindle assembly checkpoi
 nt (2008)\n 6) Drug-resistant alleles of Aurora A and Polo-like kinases (2
 010)\n 7) Identification of Aurora A as a potential therapeutic target in 
 small cell lung cancer (2011)\n 8) New technology and models for analysis 
 of protein pseudokinases (2014)\n 9) Intact PKA holoenzyme complex and cAM
 P analysis (2016)\n 10) KInome analysis of drug responses in breast and uv
 eal cancer models (2017) 
LOCATION:Babraham - The Brian Heap Seminar Room
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