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SUMMARY:Molecular dissection approaches to study diseased tissues - Dr Wal
 ker Jackson\, German Center for Neurodegenerative Diseases (DZNE)
DTSTART:20170503T150000Z
DTEND:20170503T160000Z
UID:TALK71724@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Neurodegenerative diseases (NDs) mercilessly transform a healt
 hy adult brain into a progressively dysfunctional state. Differences in cl
 inical manifestations (cognitive dysfunction in Alzheimer's disease versus
  motor dysfunction in Parkinson's disease) are the result of damage to spe
 cific brain cell types in specific brain regions. Effective therapies for 
 NDs are currently very limited\, partly due to the fact that most therapeu
 tic discovery screens have relied on limited types of cultured cells that 
 incompletely mimic the relevant disease state in the brain. In recent year
 s we have employed and refined techniques that enable the identification o
 f affected cell types and disease mechanisms in complex tissues. Although 
 our work focuses on mouse models of brain diseases (prion diseases for exa
 mple) the approaches we employ could also be adapted to other species and 
 tissues. 
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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