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SUMMARY:Bacterial lipid trafficking and outer membrane homeostasis -  Shu 
 Sin Chng (Dept Chemistry\, National University of Singapore)
DTSTART:20170410T130000Z
DTEND:20170410T140000Z
UID:TALK71948@talks.cam.ac.uk
CONTACT:28661
DESCRIPTION:Diderm bacteria\, such as Gram-negative bacteria and mycobacte
 ria\, contain two lipid bilayers in their cellular envelopes – an inner 
 membrane (IM) comprising mostly of phospholipids (PLs)\, and an outer memb
 rane (OM) that additionally contains unique glycolipids (lipopolysaccharid
 es (LPS) in Gram-negative bacteria and mycolic acids in mycobacteria). The
  OM is essential for growth in these organisms. Furthermore\, the OM serve
 s as an effective permeability barrier that in part allows Gram-negative b
 acteria and mycobacteria to survive in harsh environments\, and renders th
 em intrinsically resistant to many antibiotics. Despite the importance of 
 the OMs in these bacteria\, the processes that assemble these bilayers\, i
 n particular lipid transport\, are not well understood. In this seminar\, 
 I will describe our work in understanding and characterizing lipid traffic
 king pathways in Escherichia coli and Mycobacterium smegmatis\, and discus
 s how these systems function in maintaining lipid homeostasis in the OMs o
 f these organisms. 
LOCATION:Department of Biochemistry\, Sanger Building Lecture Theatre
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