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SUMMARY:&quot\;The Circadian Clockwork and Innate Immunity&quot\; - Prof. 
 Andrew Loudon\; Faculty of Biology\, Medicine and Health\, University of M
 anchester 
DTSTART:20170605T130000Z
DTEND:20170605T140000Z
UID:TALK71956@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Circadian rhythms are a ubiquitous feature of all living organ
 isms\, and in animal species are involved in the regulation of a wide dive
 rsity of physiological systems. It has long been established that the circ
 adian clockwork plays a key role in innate immune responses\, with more re
 cent studies now revealing that several aspects of adaptive immunity are a
 lso under the control of the circadian clock. The circadian clockwork is d
 riven by a small number of conserved genes\, which operate as a rhythmic t
 ranscriptional/translational feedback loop\, and are inter-locked to outpu
 t circuits with the cell. In animal models\, mutations of these elements i
 n immune cells commonly lead to disrupted immunity and defense\, while in 
 humans\, environmental disruption of circadian rhythms (ie shift-work) lea
 ds to perturbed immune function. I will discuss recent finding showing how
  the genetic and biochemical mechanisms linking immunity to the core circa
 dian clock of the cell operate. A key question is why the immune system is
  so tightly controlled by circadian oscillations\, and what are the implic
 ations for human health including vaccination strategies within the emergi
 ng field of chrono-immunology. 
LOCATION:Babraham - The Brian Heap Seminar Room
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