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SUMMARY:Molecular logic behind Satellite cells specification in Drosophila
  - Hadi Boukhatmi (Bray lab\, PDN)
DTSTART:20170503T163000Z
DTEND:20170503T183000Z
UID:TALK72037@talks.cam.ac.uk
CONTACT:Clara Sidor
DESCRIPTION:Adult stem cells are important for tissue maintenance and repa
 ir.  One key\nquestion is how such cells are specified and then protected 
 from differentiation.\nSimilar to vertebrates\, Drosophila have a populati
 on of residual satellite cells\n(SCs) in adult muscles that retain charact
 eristics of muscle progenitors. We have\nuncovered a role for zfh1\, a Not
 ch target\, in keeping these progenitors/SCs\nundifferentiated. Their diff
 erentiation into functional muscles is accompanied by\nexpression of a con
 served micro RNA\, mir-8/mir-200\, which targets the major “long”\nzfh
 1 isoform and decrease Zfh1 protein.  Importantly\, an alternate\, zfh1-sh
 ort\nisoform is produced at high level in the SCs. Because short zfh1 lack
 s the\ntarget-site for mir-8\, Zfh1 protein is maintained in SCs and they 
 can escape\ndifferentiation. This type of regulatory logic\, utilizing RNA
  isoforms with\ndifferential sensitivity to mIRs\, may be of general relev
 ance for progenitor\nmaintenance in other tissues. 
LOCATION:Gurdon Institute Tea Room
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