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SUMMARY:Perspectives in Chemistry: From Supramolecular Chemistry towards A
 daptive Chemistry - Professor Jean-Marie Lehn
DTSTART:20170622T100000Z
DTEND:20170622T110000Z
UID:TALK72049@talks.cam.ac.uk
CONTACT:Daphne Kaufhold
DESCRIPTION:Supramolecular chemistry is actively exploring systems undergo
 ing self-organization\, i.e. systems capable of spontaneously generating w
 ell-defined functional supramolecular architectures by self-assembly from 
 their components\, on the basis of the molecular information stored in the
  covalent framework of the components and read out at the supramolecular l
 evel through specific non-covalent interactional algorithms\, thus behavin
 g as programmed chemical systems.\n\nSupramolecular chemistry is intrinsic
 ally a dynamic chemistry in view of the lability of the interactions conne
 cting the molecular components of a supramolecular entity and the resultin
 g ability of supramolecular species to exchange their components. The same
  holds for molecular chemistry when the molecular entity contains covalent
  bonds that may form and break reversibility\, so as to allow a continuous
  change in constitution by reorganization and exchange of building blocks.
  These features define a Constitutional Dynamic Chemistry (CDC) covering b
 oth the molecular and supramolecular levels.\n\nCDC introduces a paradigm 
 shift with respect to constitutionally static chemistry. It takes advantag
 e of dynamic diversity to allow variation and selection and operates on dy
 namic constitutional diversity in response to either internal or external 
 factors to achieve adaptation. \n\nCDC generates networks of dynamically i
 nterconverting constituents\, constitutional dynamic networks\, presenting
  agonistic and antagonistic relationships between their constituents which
  may respond to perturbations by physical stimuli or to chemical effectors
 .\n\nThe implementation of these concepts points to the emergence of adapt
 ive and evolutive chemistry\, towards a chemistry of complex matter. \n\nR
 eferences\nLehn\, J.-M.\, Supramolecular Chemistry: Concepts and Perspecti
 ves\, VCH Weinheim\, 1995.\nLehn\, J.-M.\, Dynamic combinatorial chemistry
  and virtual combinatorial libraries\, Chem. Eur. J.\, 1999\, 5\, 2455.\nL
 ehn\, J.-M.\, Toward complex matter: Supramolecular chemistry and self-org
 anization\, Proc. Natl. Acad. Sci. USA\, 2002\, 99\, 4763.\nLehn\, J.-M.\,
  From supramolecular chemistry towards constitutional dynamic chemistry an
 d adaptive chemistry\, Chem. Soc. Rev.\, 2007\, 36\, 151.      \nLehn\, J.
 -M.\, Chapter 1\, in Constitutional Dynamic Chemistry\, ed. M. Barboiu\, T
 opics Curr. Chem\, 2012\, 322\, 1-32.\nLehn\, J.-M.\, Perspectives in Chem
 istry – Steps towards Complex Matter\,  Angew. Chem. Int. Ed.\, 2013\, 5
 2\, 2836-2850. \nLehn\, J.-M.\, Perspectives in Chemistry – Aspects of A
 daptive Chemistry and Materials\, Angew. Chem. Int. Ed.\, 2015\, 54\, 3276
 -3289. \n
LOCATION:Wolfson Lecture Theatre\, Department of Chemistry
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