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SUMMARY:Evolution of limb and fin regeneration - Associate Professor Igor 
 Schneider (Federal University of Pará)
DTSTART:20170726T120000Z
DTEND:20170726T130000Z
UID:TALK72434@talks.cam.ac.uk
CONTACT:Olivia Tidswell
DESCRIPTION:Salamanders are the only tetrapods capable of regenerating lim
 bs as adults\, however the evolutionary origin of this remarkable ability 
 remains unclear.  The only other sarcopterygian capable of regenerating it
 s fin endoskeleton are the lungfishes. Regeneration of dermal fin rays is 
 common among teleost fish\, yet fin endoskeleton regeneration has only bee
 n reported in living representatives of the non-teleost clade Cladistia\, 
 family Polypteridae. Therefore\, the explanation for the phylogenetic dist
 ribution of vertebrate appendage regeneration as a trait remains elusive. 
 Here\, we combine experimental studies in non-teleost actinopterygians and
  comparative RNA-seq analyses in an effort to resolve the evolutionary ori
 gin of limb and fin regeneration. First\, we demonstrate that among actino
 pterygians\, fin endoskeleton regeneration is not restricted to living rep
 resentatives of early diverging clade Cladistia\, but is also present in s
 pecies of the other two non-teleost clades: the paddlefish\, Polyodon spat
 hula (Chondrostei) and the spotted gar\, Lepisosteus oculatus (Holostei). 
 Next\, we generated transcriptome assemblies of regenerating and non-regen
 erating appendages for Polypterus\, lungfish\, axolotl\, zebrafish and mou
 se digit tips. Our comparative RNA-seq analysis provides compelling eviden
 ce for a shared appendage regeneration program between axolotl limbs and P
 olypterus and lungfish fins. Altogether\, our findings provide strong supp
 ort for an evolutionary scenario in which an appendage endoskeleton regene
 ration program first arose in osteichthyes and was subsequently lost in am
 niotes and teleosts. \n
LOCATION:Part II Lecture Theatre\, Department of Zoology
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