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SUMMARY:‘Alterations of the Polycomb machinery in cancers’ - Raphaël 
 Margueron\, Curie Institute\, Paris
DTSTART:20170502T103000Z
DTEND:20170502T113000Z
UID:TALK72458@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:The control of cell identity entails a precise orchestration o
 f gene expression programs. Although transcription factors play a crucial 
 role in the establishment and maintenance of transcriptional networks\, th
 eir action is constrained by chromatin. This nucleoproteic structure is ti
 ghtly controlled by the combination of histone modifications\, DNA methyla
 tion\, histone variant deposition and nucleosome occupancy. The proper orc
 hestration of these modifications requires a battery of enzymes\, which pr
 ecisely and dynamically regulate chromatin structure.\n\nRecent whole-geno
 me sequencing of large numbers of cancers has revealed that mutations of c
 hromatin regulators is a recurrent theme across cancers yet it remains poo
 rly understood how these mutations lead to the impairment of transcription
 al programs. We are investigating this question in the context of the Poly
 comb machinery\, a crucial actor for the maintenance of cell identity. I w
 ill present our studies aimed at understanding how the Polycomb machinery 
 function\, the consequences of its alterations and the therapeutic potenti
 al of modulating its activity.  \n
LOCATION:Sackler Lecture Theatre (Level 7)\, Cambridge Institute for Medic
 al Research
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