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SUMMARY:‘Exploring and exploiting aberrant self-fate programs in leukemi
 a’ - Dr Johannes Zuber\, Research Institute of Molecular Pathology (IMP)
 \, Vienna\, Austria
DTSTART:20170606T103000Z
DTEND:20170606T113000Z
UID:TALK72459@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:*Background:*\n\nJohannes Zuber’s lab at the Research Instit
 ute of Molecular Pathology (IMP) in Vienna develops and employs advanced R
 NAi- and CRISPR/Cas9-based functional genetic approaches to identify and m
 echanistically study cancer dependencies. Over the past years\, a particul
 ar focus has been on the exploration of chromatin-associated regulators th
 at promote aberrant self-renewal in AML and other leukemias. To identify a
 nd investigate these factors\, his lab has established a panel of conditio
 nal AML mouse models and performed candidate-focused and genome-scale gene
 tic screens for leukemia-specific dependencies. In his seminar\, he will g
 ive an update on latest findings of his research. \n\nJohannes Zuber studi
 ed medicine and received a doctorate in molecular cancer research at Chari
 té Medical School in Berlin. Following a four-year clinical residency in 
 hematology and oncology\, he joined Scott Lowe’s lab at Cold Spring Harb
 or Laboratory as a postdoc\, where he later was appointed as Clinical Rese
 arch Fellow. In 2011\, he founded his own lab at the IMP\, where he develo
 ps and employs functional-genetic approaches to identify and probe candida
 te therapeutic targets in leukemia and other cancers. He received an ERC S
 tarting Grant in 2015\, has been selected as an EMBO Young Investigator (Y
 IP)\, and has been awarded with the German Cancer Prize in 2016.\n
LOCATION:Sackler Lecture Theatre (Level 7)\, Cambridge Institute for Medic
 al Research
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