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SUMMARY:Can we predict the course of Crohn's disease? - Daniele Biasci
DTSTART:20170511T121000Z
DTEND:20170511T130000Z
UID:TALK72628@talks.cam.ac.uk
CONTACT:KC Sivaramakrishnan
DESCRIPTION:Crohn’s disease (CD) is a chronic inflammatory condition aff
 ecting the gastrointestinal tract\, thought to arise from a dysregulated i
 nteraction between the host immune system and the gut microbiota. Symptoms
  may be debilitating and usually require a lifetime of care. \n\nSome pati
 ents experience frequent relapses and require treatment with increasingly 
 potent immunosuppressants and/or surgery\, whereas others achieve prolonge
 d remission without any additional therapy. Such variability in prognosis 
 occurs in other immune-mediated diseases and can make the difference betwe
 en an excellent long-term outcome or progressive disability.\nYet\, the ca
 uses of such variation remain largely unknown. \n\nThe inability to predic
 t disease course consequently affects clinicians and patients\, leaving th
 em with a choice between two unsatisfactory options: proactive treatments 
 which may be unnecessary\, or reactive therapies which may arrive too late
 . Solving this challenge would not only enable doctors to tailor treatment
  appropriately\, but also help them design better treatments\, which could
  specifically target the biological processes responsible for frequent dis
 ease flare ups.
LOCATION:The Richard King Room\, Darwin College
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