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SUMMARY:Multiscale Modelling of Chromatin Nanostructure and its Epigenetic
  Regulation - Rosana Collepardo (Winton Programme for the Physics of Susta
 inability)
DTSTART:20170608T110000Z
DTEND:20170608T120000Z
UID:TALK72850@talks.cam.ac.uk
CONTACT:Alex Leonard
DESCRIPTION:The three-dimensional organisation of the DNA is one of the gr
 eat marvels of physical biology. By winding around a special class of prot
 eins\, the metre-long DNA manages to compress enormously to fit inside tin
 y (6 μm) nuclei\, avoid entanglement and\, moreover\, maintain exquisite 
 control over the accessibility of the information it carries. The structur
 e of this remarkable complex of DNA and proteins\, known as chromatin\, de
 termines how easy the DNA can be accessed and\, thus\, it is intimately li
 nked to gene expression regulation. However\, chromatin structure and its 
 modulation are not fully understood. In this talk\, I will explain the mul
 tiscale models that we have developed to investigate chromatin structure. 
 I will show how the structure of chromatin is much more fluid and tuneable
  than originally proposed\, which explains how chromatin achieves various 
 different roles in vivo according to the transcriptional state\, cell-cycl
 e stage\, or in response to environmental signals (Collepardo and Schlick\
 , PNAS 2014). I will also discuss how multiscale modelling can be used to 
 reveal the molecular mechanisms behind epigenetic control of chromatin str
 ucture and provide a link between epigenomes\, structure\, and gene functi
 on (Collepardo et al.\, JACS\, 2015).
LOCATION:TCM Seminar room\, 530 Mott building
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