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SUMMARY:&quot\;The roles of alternative splicing in regulating the functio
 n of intrinsically disordered regions&quot\; - Dr Robert Weatheritt\; MRC 
 Laboratory of Molecular Biology (LMB)\, University of Cambridge
DTSTART:20170705T120000Z
DTEND:20170705T130000Z
UID:TALK73024@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Alternative splicing (AS) generates extensive transcriptomic c
 omplexity. However\, how this myriad of detected AS events contribute to b
 iological functionality is not well understood. In this talk\, I will desc
 ribe how exons regulated by alternative splicing show a strong tendency to
  modulate low affinity and transient short linear motif (SLiM)-mediated pr
 otein-protein interactions. I will illustrate this with an example of a ma
 mmalian-specific set of AS events. These events regulate the inclusion of 
 repetitive GY-SLiMs within nearly all members of the heterogeneous nuclear
  ribonucleoprotein (hnRNP) A and D families of RNA binding proteins. The d
 ifferential inclusion of these exons impacts the formation of hnRNP-driven
  higher-order protein assemblies required for the regulation of target AS 
 events. 
LOCATION:Babraham - The Brian Heap Seminar Room
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