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SUMMARY:&quot\;Mechanosensitive regulation of cancer epigenetics and pluri
 potency&quot\; - Dr Johanna Ivaska\; Turku Centre for Biotechnology\, Univ
 ersity of Turku\, Finland 
DTSTART:20171010T120000Z
DTEND:20171010T130000Z
UID:TALK73026@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Cell adhesion to the extracellular matrix governs virtually ev
 ery aspect of cell behaviour. Integrins are the main cell adhesion recepto
 rs capable of triggering activation of downstream signalling pathways and 
 enabling cells to sense the stiffness of their microenvironment. Force tra
 nsmission to the cellular cytoskeleton triggers mechanochemical signalling
  influencing cell proliferation\, gene expression and cell morphology. In 
 my seminar I will describe how matrix stiffness regulates epigenetics and 
 transcription in cancer cells and how mechanical coupling of the cytoskele
 ton to matrix is essential for maintenance of pluripotency in hPSC.
LOCATION:Babraham - The Brian Heap Seminar Room
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