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SUMMARY:Phage migration along bacterial flagella: A model for the nut-and-
 bolt mechanism - Panayiota Katsamba (University of Cambridge)
DTSTART:20170614T113000Z
DTEND:20170614T123000Z
UID:TALK73078@talks.cam.ac.uk
CONTACT:Julius Bier Kirkegaard
DESCRIPTION:Bacteriophage viruses have the striking appearance of microsco
 pic spaceships. One of the most abundant entities in our planet\, they cro
 wd fluid environments in anticipation of a random encounter with bacteria\
 , and use a remarkable nanometre-size machinery for infection: fibres that
  recognise and attach to specific receptors on their victim's surface and 
 a hollow tube through which their genetic material is ejected inside the h
 ost cell cytoplasm for replication. Flagellotropic phages first attach to 
 the flagella of bacteria and find a way to reach the cell body for infecti
 on since they lack the ability to move independently. The means by which t
 hey move up the flagellum has intrigued the scientific community for over 
 30 years. In 1973 Berg and Anderson proposed the nut-and-bolt mechanism an
 d 26 years later\, Berg's group provided supporting evidence for it. Just 
 like a nut being rotated will move along a bolt\, under this scenario the 
 phage wraps itself around a flagellum possessing helical grooves (due to t
 he helical rows of flagellin molecules) and exploits the rotation of the f
 lagellum in order to passively travel along it. In this work\, we provide 
 a first-principle theoretical model for this nut-and-bolt mechanism and sh
 ow that it is able to predict experiment observations.
LOCATION:MR12\, Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
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