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SUMMARY:3D Bioprinting of Vascularized Tissues - Mark Skyler-Scott\, Harva
 rd University
DTSTART:20170717T130000Z
DTEND:20170717T140000Z
UID:TALK73147@talks.cam.ac.uk
CONTACT:Hilde Hambro
DESCRIPTION:Abstract: While tissue engineering can generate thin grafts\, 
 its ability to recapitulate the structure and function of bulk tissues and
  organs has been fundamentally limited\, in large-part by the absence of a
  readily perfusable vasculature. Absent a blood supply\, any metabolically
  demanding tissue thicker than a few hundred microns will undergo rapid co
 re necrosis due to the lack of oxygen and nutrients. 3D bioprinting has re
 cently enabled the construction of complex\, heterogeneous tissues with em
 bedded vascular networks\, which\, when connected to pumps can enable larg
 e-scale tissues to remain viable. In this talk\, I will highlight two rece
 nt advances in 3D bioprinting that can manufacture vasculature networks fr
 om the micron scale to the centimeter scale. The first method uses multima
 terial bioprinting to manufacture stem-cell laden vascularized tissues tha
 t are > 1 cm thick. The second method uses multi-photon photolithography t
 o manufacture\, with laser-precision\, complex 3D capillary networks at th
 e micron-scale.\n\nBiography: Mark Skylar-Scott was at Sidney Sussex Colle
 ge for his BA and MEng degrees. For his PhD with Prof. Fatih Yanik at the 
 Massachusetts Institute of Technology\, he developed new methods for laser
 -patterning proteins onto substrates for high-throughput quantitative neur
 odevelopmental assays. Next\, he applied this technology to perform multi-
 photon micropatterning of capillary networks. Now as a postdoc in Jennifer
  Lewis' Lab at the Wyss Institute at Harvard University\, he is developing
  3D bioprinting technologies for manufacturing large-scale vascularized ti
 ssues with applications in disease modeling\, drug screening\, and ultimat
 ely\, therapeutics.\n
LOCATION:LR5\, CUED
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