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SUMMARY:Early Life Undernutrition Alters Cardiac Muscle Development Result
 ing in Reduced Physical Activity Engagement and Increased Risk of Cardiova
 scular Disease - David P. Ferguson PhD\, RCEP \, Assistant Professor of Ki
 nesiology\, Michigan State University.
DTSTART:20170802T113000Z
DTEND:20170802T123000Z
UID:TALK73149@talks.cam.ac.uk
CONTACT:Paul Browne
DESCRIPTION:Adults who were born with low birth weight are at increased ri
 sk of developing cardiovascular disease in adulthood. However\, little is 
 known about the contribution of cardiac mechanisms to this increased disea
 se risk.  Using a mouse model we evaluated cardiovascular function at the 
 whole animal\, organ\, and cell level to determine the effect of a short e
 pisode of nutritionally-induced growth retardation on adult functional cap
 acity following nutritional rehabilitation.  Interestingly\, mice that wer
 e undernourished development presented with reduced physical activity leve
 l engagement\, impaired exercise capacity\, and impairment in contraction 
 mechanics of the heart. This phenotype is hypothesized to be due to altera
 tions in the calcium kinetics of the contracting cardiomyocytes.
LOCATION:Meeting rooms\, Level 4 Institute of Metabolic Sciences\, Addenbr
 ooke’s Treatment Centre (ATC)
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