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SUMMARY:Dynamics of Phenotypic and Genomic Evolution in a Long-Term Experi
 ment with E. coli - Professor Richard Lenski from Michigan State Universit
 y
DTSTART:20180219T163000Z
DTEND:20180219T173000Z
UID:TALK73163@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Evolution is an on-going process\, one that can be studied exp
 erimentally in organisms with rapid generations.  We have maintained 12 po
 pulations of Escherichia coli in a simple environment for over 65\,000 gen
 erations.  The aims of this experiment are to characterize the tempo and m
 ode of evolution\, and to examine the repeatability of phenotypic and geno
 mic changes.  We have quantified the dynamics of adaptation by natural sel
 ection\, documented many cases of parallel evolution\, observed changes in
  the underlying mutation rate\, and seen the appearance of a novel metabol
 ic function that transcends the usual definition of E. coli as a species. 
  We have sequenced hundreds of complete genomes to find the mutations in t
 ime-series of samples from the populations.  These genomic data provide in
 sights into the dynamic coupling of phenotypic and genotypic evolution dur
 ing periods of optimization and innovation. 
LOCATION:Babbage Lecture Theatre - New Museums Site
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