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SUMMARY:The Million Veteran Program: A Modern Mega-Cohort Within a Large H
 ealthcare System –  Progress\, Challenges and Future Directions - Dr Mic
 hael Gaziano Principal Investigator\, Million Veteran  Program and Scienti
 fic Director of the Massachusetts Veterans Epidemiology Research and Infor
 mation Center (MAVERIC)\, VA Boston Heathcare System\; Chief\, Division of
  Aging\, Brigham and Women's Hos
DTSTART:20170628T120000Z
DTEND:20170628T130000Z
UID:TALK73201@talks.cam.ac.uk
CONTACT:48007
DESCRIPTION:The revolutions in various scientific fields are making it pos
 sible to rethink our approach to how we conduct large-scale trials and obs
 ervational studies.  These include exponential growth in computing power\,
  the availability of electronic health record (EHR) data and low cost gene
 tic and other “omic” testing.  We can now use larger amounts of and mo
 re complex data to answer questions in population science.  The Million Ve
 teran Program (MVP) and our pragmatic trial program are examples of how th
 is is being executed within the VA Healthcare System.\nWith a current enro
 llment of 575\,000 participants\, MVP is the largest database of health\, 
 lifestyle\, military exposure and genetic information in the United States
 \, and is expected to enroll one million veterans.  This longitudinal coho
 rt serves as a resource for cutting-edge precision medicine research\, suc
 h as understanding the genetic risk for diseases and genetic basis for dif
 ferential response to treatment (pharmacogenomics)\, and identification of
  molecular targets for new treatments.  Participants provide a blood sampl
 e for genomic and other “omic” research\, complete health\, lifestyle 
 and military exposure surveys\, grant access to their electronic medical r
 ecords and agree to be contacted for potential participation in future res
 earch. MVP enrollment is conducted at approximately 60 sites. Three coordi
 nating centers and a toll-free information (call) center support site recr
 uitment.  Enrollment is monitored by Genomic Information System for Integr
 ated Science (GenISIS)\, a secure IT/Informatics infrastructure\, which al
 so serves as the data warehouse\, and provides a secure scientific computa
 tional environment where researchers conduct their analyses.  Concurrently
 \, the Veterans Informatics and Computing Infrastructure (VINCI) serves up
  the VA electronic medical record data for this research. \n	\nWe are coll
 aborating with the Department of Energy (DOE) to jointly leverage the VA
 ’s vast array of clinical and genomic data with DOE’s computer science
  and exa-scale computing expertise and infrastructure.  A collaboration wi
 th the Department of Defense (DOD) will allow us to enroll recently separa
 ted veterans and active duty military personnel in MVP\, starting with the
  Millennium Cohort Study enrollees beginning in 2017. Eight test projects 
 using MVP genoype and clinical data in schizophrenia\, bipolar disorder\, 
 Gulf War Illness\, PTSD\, multi-substance abuse\, cardiovascular disease\,
  metabolic disease\, chronic kidney disease\, and age-related macular dege
 neration are underway. I will present some lessons learned in curation of 
 our extensive data and early GWAS results.  \n\nOur pragmatic trial progra
 m has also launched a trial comparing two antihypertensive medications wit
 hout recruitment sites.  Participants are identified using EHR data and co
 ntacted by phone.  If they are willing to participate\, they are enrolled 
 by phone.  Progress of the study is followed by EHR.These are two of sever
 al examples of how big health data are used to conduct large-scale modern 
 epidemiology within a large healthcare system. In collaboration with many 
 partners we will be pursuing innovations in big data analytics\, statistic
 s and mathematics\, computational biology and computer science to support 
 this endeavor. This will involve interaction with other global leaders wor
 king in this new field of big data population science and groups with simi
 lar data assets such as the UKBiobank \n\n\n\nThis talk will be hosted by 
 Professor John Danesh\, Professor of Epidemiology and Medicine\, Head of D
 epartment of Public Health and Primary Care\n\n
LOCATION:Seminar Rooms\, Strangeways Research Laboratory\,  Worts Causeway
 \, CB18RN
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