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SUMMARY:Evaluation of GWAS hits as prospect targets for drug therapy: the 
 CAD/MI case - Dr Vinicius Tragante   Universitair Medisch Centrum Utrecht 
 Utrecht\, Nederland
DTSTART:20170707T120000Z
DTEND:20170707T130000Z
UID:TALK73401@talks.cam.ac.uk
CONTACT:48007
DESCRIPTION:Genome-wide association studies (GWAS) have identified so far 
 thousands of loci associated hundreds of traits. Only a few of these loci 
 are currently targets of on-market medications. Using coronary artery dise
 ase (CAD) and myocardial infarction (MI) hits as our study case\, we syste
 matically evaluated these risk loci for their druggability potential\, ass
 essing their correlation with other phenotypes\, known and predicted inter
 actions with drugs and potential side effects\, integrating multiple sourc
 es of information. To identify drugs suitable for repurposing and to ident
 ify new targets for drugs\, we created two unique pipelines integrating cu
 rrently available public data. The first is the drug repurposing pipeline:
  it uses publicly available GWAS results to predict relevant side effects 
 of targeting CAD/MI loci\, identifies drug-gene interactions and filters m
 ost suitable candidates for repurposing among drugs existing in the market
 . The second pipeline is for prioritization of gene product targets: it ca
 lculates a druggability score to estimate how dock-able the pockets of CAD
 /MI associated gene products are\, uses GWAS results to predict side effec
 ts\, excludes loci with widespread cross-tissue expression to avoid housek
 eeping and vital genes and ranked the remaining gene products. The advanta
 ges and caveats of these approaches will be presented and discussed\, alon
 g with future directions.\n\nDr. Vinicius Tragante is a researcher at Univ
 ersity Medical Center Utrecht (The Netherlands)\, where he also obtained h
 is PhD in Bioinformatics in the De Bakker and Asselbergs labs. Currently h
 e is working with GWAS analyses and post-GWAS functional assessment and dr
 uggability.\n
LOCATION:Seminar Room\, Strangeways Research Laboratory\, Worts Causeway\,
  CB18RN
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