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SUMMARY:Biomolecular self-assemblies by solid-state NMR: functional amyloi
 ds and bacterial filaments - Dr Birgit Habenstein\, CBMN UMR5248 CNRS\, In
 stitut de Biologie &amp\; Chimie des Membranes &amp\; Nanoobjets
DTSTART:20170719T093000Z
DTEND:20170719T103000Z
UID:TALK73421@talks.cam.ac.uk
CONTACT:23027
DESCRIPTION:Macromolecular self-association plays a fundamental role in nu
 merous biological processes ranging from host-pathogen interaction\, viral
  infection to the propagation of neurodegenerative disorders. The assemble
 d objects contain multiple protein subunits non-covalently arranged in sup
 ramolecular architectures that can execute a variety of cellular functions
  or cause detrimental consequences. Despite the large arsenal of biophysic
 al approaches it remains a major challenge to provide atomic details on th
 e assembled structures and the mechanisms involved in their assembly and f
 unction. Magic angle spinning solid-state NMR emerges as a powerful and ve
 rsatile technique to reveal structures\, dynamics and inter-molecular inte
 ractions in large macromolecular assemblies at the atomic scale without be
 ing limited by the size or the microscopic homogeneity of the objects.\nI 
 will present MAS solid-state NMR methods and their application to two diff
 erent types of molecular objects of pharmaceutical interest. I will concen
 trate on the insights we can obtain on functional amyloids involved in cel
 l-death signaling but I will also introduce SSNMR approaches to discern st
 ructures of molecular machines involved in bacterial infection\, the type 
 1 pilus and the type III secretion system needle.\n
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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