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SUMMARY:Rational Metallodrug Development: Novel Pharmacophores and Mode of
  Action Investigations - Christian G Hartinger\, University of Auckland\, 
 New Zealand
DTSTART:20170714T130000Z
DTEND:20170714T150000Z
UID:TALK73811@talks.cam.ac.uk
CONTACT:Alice Wood
DESCRIPTION:The mode of action of anticancer metallodrugs is crucially dep
 endent on their interactions with biological molecules. Since the discover
 y of cisplatin\, a wide variety of metal complexes have been designed for 
 the treatment of cancer and other diseases as well as for diagnostic purpo
 ses. Bioorganometallic chemistry is a thriving field of research and in pa
 rticular the development of anticancer drugs based on organometallic moiet
 ies has received a lot of attention in recent years.\n\nAs many establishe
 d chemotherapeutics have low selectivity for tumor tissue\, they cause adv
 erse effects which limit the dose that can be administered. Therefore\, we
  are aiming for the development of targeted and targeting drugs\, using or
 ganometallic fragments to interact selectively with a biomolecular target 
 or to be selectively transported to and accumulated in tumor tissue.\n\nA 
 brief overview of my groups recent contributions to the field of anticance
 r bioorganometallics will be given in this lecture\, including recent adva
 nces in our understanding of the modes of action to support future drug de
 sign. This presentation will focus on novel metal-based pharmacophores and
  the application of novel bioanalytical methods and their development\, an
 d the translation of these methods to identify new metal-based pharmacopho
 res with promising biological properties.\n\n
LOCATION:Unilever  Lecture Theatre\,  Department of Chemistry
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