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SUMMARY:Coding and non-coding cancer mutations - Prof. Dr Núria López-Bi
 gas\, ICREA Research Professor\, IRB Barcelona
DTSTART:20170814T150000Z
DTEND:20170814T160000Z
UID:TALK74301@talks.cam.ac.uk
CONTACT:46487
DESCRIPTION:Somatic mutations are the driving force of cancer genome evolu
 tion. The rate of somatic mutations appears to be greatly variable across 
 the genome due to variations in chromatin organization\, DNA accessibility
  and replication timing. However\, other variables that may influence the 
 mutation rate locally are unknown. I will discuss recent findings from our
  lab on how DNA-binding proteins and differences in exons and introns infl
 uence mutation rate. These finding have important implications for our und
 erstanding of mutational and DNA repair processes and in the identificatio
 n of cancer driver mutations. Given the evolutionary principles of cancer\
 , one effective way to identify genomic elements involved in cancer is by 
 tracing the signals left by the positive selection of driver mutations acr
 oss tumours. We analyze thousands of tumor genomes to identify driver muta
 tions in coding and non-coding regions of the genome.\n\n\nBio\n\nNuria Lo
 pez¬-Bigas is an ICREA Research Professor at the Barcelona Institute for 
 Research in Biomedicine and associate professor at the University Pompeu F
 abra. She leads the Biomedical Genomics lab (http://bbglab.irbbarcelona.or
 g)\, focused on the study of cancer from a genomics perspective. She is pa
 rticularly interested in the identification of cancer driver mutations\, g
 enes and pathways across tumor types\, and in understanding mutational pro
 cesses in cancer cells. Her lab has actively participated in the major can
 cer genomics projects\, including the International Cancer Genomics Consor
 tia (ICGC) and The Cancer Genome Atlas (TCGA).\n
LOCATION:CRUK CI Room 009/009A
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