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SUMMARY:Mechanosensing and endosomal traffic – new vulnerabilities in br
 east cancer - Johanna Ivaska\, Turku Centre for Biotechnology\, University
  of Turku\, Finland
DTSTART:20180118T130000Z
DTEND:20180118T140000Z
UID:TALK74331@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Tissue homeostasis is dependent on the spatially controlled lo
 calization of specific cell types and the correct composition of the extra
 cellular stroma. Integrin mediated adhesions\, in conjunction with the act
 in cytoskeleton\, allow cells to sense the stiffness of the surrounding ex
 tra-cellular matrix (ECM). Conversely\, cells exert acto-myosin and integr
 in dependent forces to remodel and organize the surrounding ECM. In cancer
 \, stiffening of the tumor stroma is considered as an instrumental contrib
 utor to tumor progression. However\, the mechanisms how the stromal ECM re
 gulates cancer progression is not fully understood. I will describe our re
 cent findings on the interrelationship between cancer cell mediated ECM re
 modelling and ECM induced mechanochemical signals regulating transcription
  of growth promoting pathways in cancer cells. Endosomal trafficking of in
 tegrins and receptor tyrosine kinases (RTK) is a central mechanism for reg
 ulating their cell surface availability and downstream signaling. Co-endoc
 ytosis of integrins and RTKs and endosomal cross-talk between these recept
 ors is implicated in oncogenic transformation. I will describe our recent 
 observations for endosomal signalling driving breast cancer tumorigenic pr
 operties.\n\n
LOCATION:CRUK CI Lecture Theatre
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