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SUMMARY:“Symmetry breaking and self-organisation in mouse development”
  - Dr Takashi Hiiragi\; EMBL
DTSTART:20170801T130000Z
DTEND:20170801T140000Z
UID:TALK75101@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:A defining feature of living systems is the capacity to break 
 symmetry and generate well-defined forms and patterns through self-organis
 ation. Our group aims to understand the principle of multi-cellular self-o
 rganisation using a well-suited model system: early mouse embryos. Mammali
 an eggs lack polarity and thus symmetry is broken during early embryogenes
 is. This symmetry breaking results in the formation of a blastocyst consis
 ting of two major cell types\, the inner cell mass and the trophectoderm\,
  each distinct in its position and gene expression. Our recent studies une
 xpectedly revealed that morphogenesis and gene expression are highly dynam
 ic and stochastically variable during this process. Determining which sign
 al breaks the symmetry and how the blastocyst establishes a reproducible s
 hape and pattern despite the preceding variability remains fundamental ope
 n questions in mammalian development. We have recently developed a unique 
 set of experimental frameworks that integrate biology and physics. With th
 is we aim to understand how molecular\, cellular and physical signals are 
 dynamically coupled across the scales for self-organisation during early m
 ammalian development.
LOCATION:Babraham - The Brian Heap Seminar Room
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