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SUMMARY:Clonal evolution of cancer: lessons from the mouse - Allan Balmain
 \, UCSF Helen Diller Comprehensive Family Cancer Centre
DTSTART:20180517T120000Z
DTEND:20180517T130000Z
UID:TALK77321@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Mouse cancer models have helped us to develop and understand t
 he concept of multistage tumour development from single initiated cells to
  metastasis. We know that advanced tumours both in mouse and human are het
 erogeneous at the genetic level\, comprising many subclones that contribut
 e to development of drug resistance and poor patient outcomes.  A combinat
 ion of genetic and chemical models of carcinogenesis in the mouse is uniqu
 ely able to provide insights into the clonal evolution of cancers at the c
 ellular level\, by labelling individual cells\, either in the whole tissue
  or in subpopulations of stem cells\, and following their fate changes at 
 different stages of tumorigenesis. We have used the DMBA/TPA model of squa
 mous carcinoma development in the skin of the K5CreER-Confetti mouse toget
 her with stage-specific lineage tracing to analyze the clonality of initia
 tion\, development of benign tumours\, progression to carcinomas and furth
 er to metastasis. Additional models in which specific stem cell population
 s can be traced during normal development and tumor formation have enabled
  us to investigate the relationship between normal and cancer stem cells\,
  the impact of “cell of origin” on tumour phenotype\, and the probabil
 ity of malignant progression from “high risk” benign tumours.  \n\n
LOCATION:CRUK CI Lecture Theatre
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