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SUMMARY:Slimming Down Through Frustration - Dr Martin Lenz\, Université P
 aris-Sud
DTSTART:20171122T141500Z
DTEND:20171122T151500Z
UID:TALK77941@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:Controlling the self-assembly of supramolecular structures is 
 vital for\nliving cells\, and a central challenge for engineering at the n
 ano- and\nmicroscales. Nevertheless\, even particles without optimized sha
 pes can\nrobustly form well-defined morphologies. This is the case in nume
 rous\nmedical conditions where normally soluble proteins aggregate into\nf
 ibers. Beyond the diversity of molecular mechanisms involved\, we\npropose
  that fibers generically arise from the aggregation of irregular\nparticle
 s with short-range interactions. Using minimal models of\nfrustrated aggre
 gating particles\, we demonstrate robust fiber formation\nfor a variety of
  particle shapes and aggregation conditions. Geometrical\nfrustration play
 s a crucial role in this process\, and accounts for the\nrange of paramete
 rs in which fibers form as well as for their\nmetastable\, yet long-lived 
 character.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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