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SUMMARY:Three phases of genome sequencing and their consequences for scien
 ce and medicine - Professor Richard Durbin FRS\,      Department of Geneti
 cs\, University of Cambridge and Wellcome Trust Sanger Institute\, Cambrid
 ge
DTSTART:20171106T180000Z
DTEND:20171106T190000Z
UID:TALK77971@talks.cam.ac.uk
CONTACT:Beverley Larner
DESCRIPTION:Over the last 20 years genome sequencing has had a profound im
 pact on the biological sciences and related applications in medicine and a
 griculture.  There have been three phases\, each associated with a change 
 in technology.  The first\, in which Fred Sanger’s sequencing chemistry 
 was automated in the first sequencing machines\, led to the reference geno
 me sequences of human and a few other key species. This enabled genomic bi
 ology.  In the second phase\, highly parallel “next generation” short 
 read sequencing technologies allowed sequencing thousands of humans and in
 dividuals from other species for which a reference was already available\,
  giving us the ability to study genetic variation directly.  This has led 
 to rapidly increasing applications of DNA sequencing in clinical medicine\
 , and has connected two scientific areas\, population genetics and molecul
 ar biology.  In the last few years\, new single molecule sequencing techno
 logies have become viable at scale\, giving sequencing reads hundreds of t
 imes longer than the previous methods\, which allow us to efficiently dete
 rmine from scratch the genome sequences of arbitrary species.  Extrapolati
 ng long term trends of cost reduction and throughput increases\, we can se
 e we are entering a third phase of genome sequencing in which we will sequ
 ence all million or so known species\, with potential major consequences f
 or the study of diversity and evolution\, and for conservation.
LOCATION:Bristol-Myers Squibb Lecture Theatre\, Department of Chemistry
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