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SUMMARY:Sequential Neurogenesis Establishes the Different Sensory Modaliti
 es of the Trigeminal Ganglia - Sophie Caron\, Department of Molecular and 
 Cellular Biology\, Harvard University
DTSTART:20071003T100000Z
DTEND:20071003T110000Z
UID:TALK8005@talks.cam.ac.uk
CONTACT:Greg Jefferis
DESCRIPTION:Sensory ganglia are nerve centers containing neurons with diff
 erent sensory modalities. How this cellular diversity is generated remains
  largely unknown. We addressed this question using the zebrafish trigemina
 l sensory ganglia as a model system. We found that the trigeminal ganglia 
 are composed of early-born and late-born neurons. A specific subpopulation
 \, defined by the expression of the channel trpA1b\, only forms during ear
 ly periods of neurogenesis. When we manipulated the trigeminal ganglia suc
 h that they are solely formed from late-born neurons\, the trpA1b expressi
 ng neurons are absent. Consequently\, such embryos are insensitive to must
 ard oil\, a pungent chemical detected by TrpA1b\, but respond to touch. Ou
 r results indicate that timing of neurogenesis underlies the diversificati
 on of sensory neurons.
LOCATION:Basement Seminar Room\, Department of Zoology
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