BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Talks.cam//talks.cam.ac.uk// X-WR-CALNAME:Talks.cam BEGIN:VEVENT SUMMARY:Turing revisited: the chemo-mechanical bases of morphogenesis in s oft living matter - Pasquale Ciarletta (Politecnico di Milano\; CNRS (Cen tre national de la recherche scientifique)) DTSTART:20170919T084000Z DTEND:20170919T092000Z UID:TALK80091@talks.cam.ac.uk CONTACT:INI IT DESCRIPTION: Life phenomena result from the mutual equilib rium between the living matter and the surrounding media. A network of s ervo-mechanisms physiologically restores the stable equilibrium between the interior matter of a living entity in the face of external perturbat ive agents. In particular\, living cells can balance exogenous and endog enous forces using an iterative process\, also known as mechano-reciproc ity. Hence\, not only living matter can adapt through epigenetic remodel ling to the external physical cues\, but it can also respond by activati ng gene regulatory processes\, which may also drive the onset of patholo gies\, e.g. solid tumours. Moreover\, living materials have the striking ability to change actively their micro-structural organization in order t o adjust their functions to the surrounding media\, developing a state o f internal tension\, which even persists after the removal of any extern al loading. This complex mechanical and biochemical interaction can fina lly control morphogenesis during growth and remodelling\, leading to sha pe instabilities characterized by a complex morphological phase diagram

In this lecture\, I will introduce few mathematical mode lling approaches to mechanobiology and morphogenesis in living materials [1]\, with several applications concerning solid tumours [2\,3]\, gastr o-intestinal organogenesis [4]\, bacterial colonies [5] and nerve fibers [6].

[1] Ciarletta P\, Preziosi L\, Maugin GA.Mechanobio logy of interfacial growth. JOURNAL OF
THE MECHANICS AND PHYSICS OF SOLIDS\, 2013\, vol. 61\, p. 852-872\;
[2] Giverso\, C.\,  \; Ciarletta\, P. (2016). Tumour angiogenesis as a chemo-mechanical surf ace instability. SCIENTIFIC REPORTS\, 6.
[3] Ciarletta P. Buckli ng instability in growing tumour spheroids. PHYSICAL REVIEW LETTERS\, 20 13\, vol. 110.
[4] Ciarletta P.\, Balbi V.\, Kuhl\, E. Pattern sel ection in growing tubular tissues. PHYSICAL
REVIEW LETTERS\, 201 4\, 113\, 248101.
[5] Giverso\, C.\, Verani M.\, Ciarletta P. Bran ching instability in expanding bacterial colonies.
JOURNAL OF TH E ROYAL SOCIETY INTERFACE\, 2015\, 12\, 20141290
[6] Taffetani M.\ , Ciarletta P. Elastocapillarity can control the formation and the morph ology
of beads-on-string structures in solid fibers\, PHYSICAL REV IEW E\, 2015\, 91\, 032413 LOCATION:Seminar Room 1\, Newton Institute END:VEVENT END:VCALENDAR