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SUMMARY:&quot\;Infection and Autoimmunity: Co-habitation may be a good thi
 ng.&quot\; - Prof. Anne Cooke\, Dept. of Pathology\, University of Cambrid
 ge
DTSTART:20071121T163000Z
DTEND:20071121T173000Z
UID:TALK8031@talks.cam.ac.uk
CONTACT:Laurence Tiley
DESCRIPTION:The development of most autoimmune diseases is under the contr
 ol of many genes but additionally is regulated by environmental factors. T
 his is exemplified by studies of identical twins where the concordance rat
 e for development of Type 1 diabetes is around 40%. Several autoimmune dis
 eases\, including Type 1 diabetes\, are increasing in incidence in the dev
 eloped world at a rate faster than can be accounted for by genetic change.
  Our study of environmental factors modulating autoimmunity has highlighte
 d a key role for infection in reducing the incidence of Type 1 diabetes. W
 e think that protection from diabetes arises through an interaction betwee
 n the infectious agent and the innate immune system such that circuits whi
 ch regulate the autoimmune response are reinforced.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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