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SUMMARY:Salmonella and its antigens: T cells\, B cells and some controvers
 ies - Dr Adam Cunningham\, MRC Centre for Immune Regulation\, Division of 
 Immunity and Infection\, University of Birmingham
DTSTART:20080220T163000Z
DTEND:20080220T173000Z
UID:TALK8054@talks.cam.ac.uk
CONTACT:Laurence Tiley
DESCRIPTION:Salmonella infections have devastating effects worldwide wheth
 er they are typhoidal or non-typhoidal in origin and studying immunity to 
 Salmonella is essential in the search for improved vaccines. Additionally\
 , Salmonella infections are a potential paradigm for understanding intrace
 llular infections\, how T helper 1 responses develop\, the induction of B 
 cells and how bacterial components influence immunity.\n\nIn this talk I w
 ill discuss how CD4 T cell responses to Salmonella develop and are maintai
 ned. In particular I will focus on the response to the immunodominant anti
 gen flagellin and how CD30 and OX40 are required for activated CD4 T cell 
 survival.\n\nIn the second part of the talk I will focus on the highly aty
 pical B cell response Salmonella induces. I will demonstrate that the resi
 lience of this response even in the absence of CD28 or CD40L appears to be
  due partially to the rapid recruitment of B1b cells. Our data indicate th
 at the outer membrane porin proteins OmpF and OmpC are targets of this B1b
  response. This is demonstrated by B1b induction by purified OmpF and OmpC
  and an abrogated induction by bacteria that lack these proteins. Furtherm
 ore transfer of B1b cells into B cell-deficient mice and vaccination could
  confer some protection against infection with Salmonella.\n\nLastly\, I w
 ill briefly introduce data that query whether antibody to LPS is protectiv
 e and whether CD4 T cells play a role in orchestrating protection during t
 he early stages of secondary encounter with Salmonella.\n\n
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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