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SUMMARY:&quot\;Post-transcriptional regulation dictates T cell functionali
 ty in health and disease&quot\; - Dr Fiamma Salerno\; Sanquin Blood Supply
  Foundation\, Amsterdam\,The Netherlands 
DTSTART:20171110T130000Z
DTEND:20171110T140000Z
UID:TALK81041@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Memory T cells are critical to protect us from recurring infec
 tions. Their instantaneous reactivity to pathogens is empowered by persist
 ent expression of cytokine mRNA. How aberrant cytokine production of this 
 pre-formed mRNA is prevented in the absence of infection remains\, however
 \, unresolved. Here\, I will discuss how post-transcriptional regulation t
 hrough AU-rich elements is key to block chronic production of cytokines in
  memory T cells. Importantly\, for swift recall responses to infection\, t
 his translational block must be rapidly relieved and pre-formed cytokine m
 RNA serves as ready-to-be-translated template. This switch is achieved by 
 loss of the suppressive capacity of the RNA-binding protein ZFP36L2. Final
 ly\, I propose that altering the post-transcriptional regulation of IFN pr
 oduction can be exploited to improve the efficacy of T cell therapy for ca
 ncer treatment.
LOCATION:Babraham - The Cambridge Building\; Kings Hedges Room
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