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SUMMARY:Jak/Stat regulates dpp transcription in support cells to maintain 
 Drosophila ovarian niche - Acaimo Gonzalez-Reyes\, Universidad de Sevilla
DTSTART:20071018T150000Z
DTEND:20071018T160000Z
UID:TALK8115@talks.cam.ac.uk
CONTACT:Rachel Aucott
DESCRIPTION:The existence of specialised regulatory microenvironments or n
 iches that sustain stable stem cell populations is well documented in many
  tissues.  However\, the specific mechanisms by which niche support (or st
 romal) cells govern stem cell maintenance remain largely unknown. Here we 
 demonstrate that removal of the Jak/Stat pathway in support cells of the/ 
 Drosophila/ ovarian niche leads to germline stem cell (GSC) loss by differ
 entiation.  Conversely\, ectopic Jak/Stat activation in support cells indu
 ces GSC tumours\, implying the presence of a signal relay between the stro
 mal compartment and GSCs.  We further show that ectopic Jak/Stat signallin
 g in support cells augments/ dpp/ mRNA levels and increases the range of D
 pp signalling\, a BMP2 orthologue known to act as a niche extrinsic factor
  required for female GSC survival and division.  Our results provide stron
 g evidence for a model in which Jak/Stat signalling in support cells regul
 ates/ dpp/ transcription to maintain the adjacent GSCs in an undifferentia
 ted state and to define niche size."
LOCATION:Part II Lecture Theatre\, Department of Zoology
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