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SUMMARY:Cancelled - Intracellular Salmonella persisters  - Dr. Sophie Hela
 ine\, MRC Centre for Molecular Bacteriology and Infection\, Imperial Colle
 ge London
DTSTART:20180131T160000Z
DTEND:20180131T170000Z
UID:TALK82211@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Persister bacteria are non-growing\, antibiotic insensitive ce
 lls\, the progeny of which are sensitive to antibiotics. Bacterial persist
 ence is a common phenotype expressed by a large number of bacterial specie
 s and is thought to be responsible for relapsing infections. During Salmon
 ella infection of macrophages an important proportion of bacteria enter a 
 persister state via the action of class II toxin-antitoxin modules. These 
 toxin-antitoxin modules encode a stable toxin that inhibits a vital cellul
 ar process and a labile\, neutralising antitoxin\, which is degraded under
  conditions of stress but otherwise binds and inactivates the toxin. We in
 vestigate the activity of three of these toxins\, which are acetyltransfer
 ases and how bacteria recover from the persistent state.
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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