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SUMMARY:From vesicles to responsive artificial tissues - Emma Talbot\, Has
 eloff Lab
DTSTART:20180201T130000Z
DTEND:20180201T133000Z
UID:TALK82691@talks.cam.ac.uk
CONTACT:Pallavi Singh
DESCRIPTION:Lipid vesicles provide the perfect chassis for an artificial c
 ell\, enabling compartmentalisation of internal material within a surround
 ing bilayer membrane. The encapsulation of DNA transcription and translati
 on machinery allows the simplified mimicry of real cells by enabling confi
 ned protein expression. Small molecules may pass through the membrane allo
 wing communication between vesicles\, while macromolecules remain trapped 
 inside in the absence of pores or cross-membrane transporters. \n\nFor mos
 t artificial cells the membrane is just a boundary that cordons within the
  functional components of interest. In real cells\, the membrane is a hete
 rogeneous bilayer structure largely composed of lipids\, and incorporating
  membrane proteins which are vital to many cell functions including signal
 ling. The complex interplay between lipid patterning into phase separated 
 domains\, and the association of membrane proteins with those domains has 
 been shown to affect signal transduction and receptor functionality. As su
 ch\, membrane patterning and controlled spatial organisation of membrane-b
 ound cargo is an important feature which should not be overlooked in artif
 icial cells. Here\, we work towards generating lipid assemblies with contr
 olled geometrical curvature to drive lipid and protein patterning on the m
 embrane of artificial cells in a pre-defined manner. \n
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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